血小板源性生长因子BB抗体
规格：1mg/1ml
英文名： PDGFBB
别名： PDGF BB; PDGF-BB; platelet derived growth factor-BB; Becaplermin; C sis; FLJ12858; Oncogene SIS; PDG B chain; PDGB; PDGF 2; PDGF B; PDGF B chain; PDGF2; PDGFB; PDGFB/COL1A1 fusion gene; Platelet deriv
分子量： 12kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PDGF-B
交叉反应：Human, Mouse, Rat,
细胞定位：分泌型蛋白
血小板源性生长因子BB抗体产品介绍：background: Platelet Derived Growth Factor (PDGF) is the major serum mitogen for cells of mesenchymal origin in humans. The biologically active protein is a dimer composed of two related polypeptides designated A and B, the dimers being connected by disulfide bonds. The PDGF protein has been implicated both directly as well as indirectly in several pathological states including neoplasia, arthritis, arteriosclerosis and bone marrow sclerosis. Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation 血小板源性生长因子BB抗体of heterodimers with PDGFA. Subunit: Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1. Subcellular Location: Secreted. Note=Released by platelets upon wounding. Tissue Specificity: Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.血小板源性生长因子BB抗体 DISEASE: Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB. Similarity: Belongs to the PDGF/VEGF growth factor family. Gene ID: 5155 Database links: Entrez Gene: 5155 Human Entrez Gene: 18591 Mouse Entrez Gene: 24628 Rat Omim: 190040 Human SwissProt: P01127 Human SwissProt: P31240 Mouse SwissProt: Q05028 Rat Unigene: 1976 Human Unigene: 144089 Mouse Unigene: 198230 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 生长因子和**（ Growth Factor and Hormones） 血小板源性生长因子（PDGF），是由A、B两条多肽链通过二硫键连接而成的同型或异型二聚体。包括三种形式：PDGF-AA、PDGF-BB、PDGF-AB.分子量为28～35KD。 PDGF-BB也是PDGF家族成员，是一种碱性蛋白，可促进细胞分裂并促进神经元的生长， PDGF-BB的正常表达对于神经系统的发育和成熟起着一定的作用。
血小板源性生长因子BB抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid