IgG-Fc片断受体转运蛋白α抗体
规格：1mg/1ml
英文名： FCGRT
别名： Alpha chain; Fc fragment of IgG, receptor transporter, alpha; FCGRN_HUMAN; FCGRT; FcRn alpha chain; FCRN; FCRN, alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG rece
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FCGRT/Fc
交叉反应：Human, Mouse, Rat, Dog, Sheep,
细胞定位：细胞膜
IgG-Fc片断受体转运蛋白α抗体产品介绍：background: FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn ? chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a majorIgG-Fc片断受体转运蛋白α抗体 constituent for ensuring IgG are the longest lived of all plasma proteins. Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. Subunit: FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity).IgG-Fc片断受体转运蛋白α抗体 Subcellular Location: Cell membrane. Similarity: Belongs to the immunoglobulin superfamily. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. Database links: Entrez Gene: 2217 Human Omim: 601437 Human SwissProt: P55899 Human Unigene: 111903 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IgG-Fc片断受体转运蛋白α抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞膜受体 血管内皮细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid