转录起始因子TFIID亚基4B抗体
规格：1mg/1ml
英文名： TAF4B
别名： TAF(II)105; TAF2C2; TAF4b RNA polymerase II, TATA box binding protein (TBP) associated factor, 105kDa; TAFII 105; TAFII105; TAFII105ALPHA; TATA box binding protein (TBP) associated factor 4B; TATA box
分子量： 91kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TAF4B
交叉反应：Human, Mouse,
细胞定位：细胞核 细胞浆
转录起始因子TFIID亚基4B抗体产品介绍：background: TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] Function: Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with 转录起始因子TFIID亚基4B抗体OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. Subunit: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Heterodimerizes with TAF12/TFII20 via the C-terminal H2A-like histone-fold domain. This heterodimer forms a histone-like octamer with the TAF6/TAFII70-TAF9/TAFII31 heterodimer. Interacts with P65/RELA homodimers and P65/RELA-REL heterodimers. Interaction with POU2AF1, via its C-terminal activation domain, is required for octamer-dependent transcription. Subcellular Location: Nucleus. Cytoplasm. Export into the cytoplasm is mediated by a CRM1-independent nuclear 转录起始因子TFIID亚基4B抗体export pathway and not by phosphorylation. Tissue Specificity: Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells. Post-translational modifications: Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA). DISEASE: The disease is caused by mutations affecting the gene represented in this entry. Disease description:A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Similarity: Belongs to the TAF4 family. Contains 1 histone-fold domain. Contains 1 TAFH (NHR1) domain. Database links: Entrez Gene: 6875 Human Omim: 601689 Human SwissProt: Q92750 Human Unigene: 369519 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录起始因子TFIID亚基4B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转录调节因子 b-**细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid