胆绿素还原酶抗体
规格：1mg/1ml
英文名： Biliverdin Reductase
别名： Biliverdin Reductase; Biliverdin IX alpha reductase; Biliverdin reductase A; BLVR A; BLVR; BLVRA; BVR A; BVR; BVRA; zinc-metalloprotein; BIEA_HUMAN.
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BLVRA/Bi
交叉反应：Human, Mouse, Rat, Pig,
细胞定位：细胞浆
胆绿素还原酶抗体产品介绍：background: In human liver cytosolic fractions, four forms of biliverdin reductase have been identified, including two biliverdin-IX Beta reductases and two biliverdin-IX Alpha reductases, designated isozymes I and II and isozymes III and IV, respectively. Biliverdin reductase A (BLVRA), also designated biliverdin-IX Alpha-reductase, belongs to the GFO/iIDH/MocA family and the biliverdin reductase subfamily. The gene that encodes this cytoplasmic protein maps to chromosome 7p14-cen. BLVRA reduces biliverdin IX ?(the ?methene bridge of the open tetrapyrrole) to bilirubin with the concomitant oxidation of an NADH or NADPH cofactor (bilirubin + NADP+ = biliverdin + NADPH). BLVRA is expressed primarily in liver. Function: Biliverdin Reductase (BVR) catalyzes the final step in the heme metabolic pathway, the reduction of biliverdin IX{alpha} to bilirubin, with the concomitant oxidation of a NADH or NADPH cofactor. The enzyme remains unique among all biological catalysts 胆绿素还原酶抗体described to date in having a dual pH/cofactor-dependent activity profile. Human biliverdin reductase (hBVR) has been recently shown to be a Ser/Thr/Tyr kinase in the MAPK insulin/insulin-like growth factor 1 (IGF1)-signaling cascade. BVR together with its substrate, biliverdin, and product, bilirubin, have recently been revealed to be important players in cellular signal transduction pathways, gene expression and oxidative response. These features make BVR unusually interesting and unique among all enzymes characterized to date. Subunit: Monomer. Subcellular Location: Cytoplasmic Tissue Specificity: Liver. DISEASE: Defects in BLVRA are the cause of hyperbiliverdinemia(HBLVD) [MIM:614156]. HBLVD is a condition characterized by 胆绿素还原酶抗体a greendiscoloration of the skin, urine, serum, and other bodily fluids.It is due to increased biliverdin resulting from inefficientconversion to bilirubin. Affected individuals appear to havesymptoms only in the context of obstructive cholestasis and/orliver failure. In some cases, green jaundice can resolve afterresolution of obstructive cholestasis. Similarity: Belongs to the Gfo/Idh/MocA family. Biliverdinreductase subfamily. Database links: Entrez Gene: 644 Human Entrez Gene: 109778 Mouse Entrez Gene: 116599 Rat Omim: 109750 Human SwissProt: P53004 Human SwissProt: Q9CY64 Mouse SwissProt: P46844 Rat Unigene: 488143 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胆绿素还原酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 激酶和磷酸酶 新陈代谢
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid