液泡蛋白分选蛋白29抗体
规格：1mg/1ml
英文名： VPS29
别名： DC15; DC7; DKFZp564F0223; FLJ20492; hVPS29; PEP11; PEP11 homolog; Retromer protein; Vacuolar protein sorting 29; Vacuolar protein sorting 29 (yeast homolog); Vacuolar protein sorting 29 (yeast); Vacuo
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human VPS29
交叉反应：Human, Mouse, Rat, Chicken, Rabbit, Guinea Pig,
细胞定位：细胞浆 细胞膜
液泡蛋白分选蛋白29抗体产品介绍：background: This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. [provided by RefSeq,液泡蛋白分选蛋白29抗体 Aug 2013] Function: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro). Subcellular Location: Cytoplasm. Membrane. Endosome membrane. Tissue Specificity: Ubiquitous. Highly expressed in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain. Similarity: Belongs to the VPS29 family. Database links: Entrez Gene: 51699 Human Entrez Gene: 液泡蛋白分选蛋白29抗体56433 Mouse Entrez Gene: 288666 Rat Entrez Gene: 573437 Zebrafish Omim: 606932 Human SwissProt: Q5ZIL2 Chicken SwissProt: Q9UBQ0 Human SwissProt: Q9QZ88 Mouse SwissProt: B2RZ78 Rat SwissProt: Q7ZV68 Zebrafish Unigene: 600114 Human Unigene: 216528 Mouse Unigene: 445844 Mouse Unigene: 2547 Rat Unigene: 76673 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
液泡蛋白分选蛋白29抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid