磷酸肌醇磷脂酶C抗体
规格：1mg/1ml
英文名： PLCD1/NDNC3
别名： 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta 1; NDNC3; Phosphoinositide phospholipase C; Phosphoinositide phospholipase C delta 1; Phospholipase C delta 1; Phospholipase C III; PLC
分子量： 86kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PLCD1/ND
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
细胞定位：细胞浆
磷酸肌醇磷脂酶C抗体产品介绍：background: This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol磷酸肌醇磷脂酶C抗体 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. DISEASE: The disease is caused by mutations affecting the gene represented in this entry. Disease description:A nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more磷酸肌醇磷脂酶C抗体 transverse bands (leukonychia striata) or white spots (leukonychia punctata). Similarity: Contains 1 C2 domain. Contains 2 EF-hand domains. Contains 1 PH domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC X-box domain. Gene ID: 5333 Database links: Entrez Gene: 281986 Cow Entrez Gene: 5333 Human Entrez Gene: 18799 Mouse Entrez Gene: 100627099 Pig Entrez Gene: 24655 Rat Omim: 602142 Human SwissProt: P51178 Human SwissProt: Q8R3B1 Mouse SwissProt: P10688 Rat Unigene: 80776 Human Unigene: 23963 Mouse Unigene: 12324 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸肌醇磷脂酶C抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid