SNRP70蛋白抗体
规格：1mg/1ml
英文名： SNRP70
别名： RNPU1Z; Rnulp70; RPU1; Small nuclear ribonucleoprotein 70 (U1); Small nuclear ribonucleoprotein 70kD polypeptide (RNP antigen); Small nuclear ribonucleoprotein 70kDa (U1); Small nuclear ribonucleoprot
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SNRP70
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig,
细胞定位：细胞核
SNRP70蛋白抗体产品介绍：background: SNRP70 is an RNA-binding protein that is a specific component of the U1 small nuclear ribonucleoprotein complex and constitutes the major anti-(U1) RNP autoimmune antigen. SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA. Subunit: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRP70蛋白抗体SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SCNM1. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Interacts with dephosphorylated SFRS13A and SFPQ. Interacts withSNRP70蛋白抗体 NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2. Subcellular Location: Nuclear. Post-translational modifications: The N-terminus is blocked. Extensively phosphorylated on serine residues in the C-terminal region. Similarity: Contains 1 RRM (RNA recognition motif) domain. Database links: Entrez Gene: 6625 Human Entrez Gene: 20637 Mouse Entrez Gene: 361574 Rat Omim: 180740 Human SwissProt: Q1RMR2 Cow SwissProt: P08621 Human SwissProt: Q62376 Mouse Unigene: 467097 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SNRP70蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid