载脂蛋白L1抗体
规格：1mg/1ml
英文名： APOL1
别名： APO L; Apo-L; APOL; APOL I; ApoL-I; APOL1; Apolipoprotein L1; APOL1_HUMAN; APOLI; APOL1; APOL 1; APOL-1; Apolipoprotein L; Apolipoprotein L I; Apolipoprotein L-I; Apolipoprotein L1; Apolipoprotein L-1
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human APOL1/Ap
交叉反应：Human,
细胞定位：分泌型蛋白
载脂蛋白L1抗体产品介绍：background: Apolipoproteins are protein components of plasma lipoproteins (1). The apolipoprotein L gene family encodes six highly homologous proteins designated apoL-I to -VI, which are associated with large high density type lipoproteins (HDL) (2,3). The human apoL family maps to chromosome 22q12.1-13.1 within a 127,000-bp region (4). ApoL has been characterized as a pancreas specific, 383-amino acid protein that contains a 12-amino acid secretory signal peptide (4). The apoL genes have TATA-less promoters and contain putative sterol regulatory elements, suggesting that transcription of these genes may be coordinated with that of the low density lipoprotein receptor and genes in pathways involving the synthesis of triglycerides and cholesterol (3). ApoL homologs can undergo 10 fold changes in expression during atherosclerotic changes in vascular endothelial cells, which includes the inflammatory reaction of atherosclerotic lesions (5). Function: May play a载脂蛋白L1抗体 role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. Subunit: In plasma, interacts with APOA1 and mainly associated with large high density lipoprotein particles. Subcellular Location: Secreted. Tissue Specificity: Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen. Post-translational modifications: Phosphorylation sites are present in the extracelllular medium. DISEASE: Defects in APOL1 are the cause of focal segmental glomerulosclerosis type 4 (FSGS4) [MIM:612551]. It is a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in 载脂蛋白L1抗体proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Similarity: Belongs to the apolipoprotein L family. Database links: Entrez Gene: 8542 Human Omim: 603743 Human SwissProt: O14791 Human Unigene: 114309 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
载脂蛋白L1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid