原肌球蛋白抗体
规格：1mg/1ml
英文名： TPM2
别名： AMCD1; Beta tropomyosin muscle; BETA-TM; DA1; DA2B; EPITHELIAL TROPOMYOSIN; FIBROBLAST MUSCLE TYPE TROPOMYOSIN; MGC109519; NEM4; TM2; TMSB; TPM2; TROP-2; TROPOMYOSIN 2; Tropomyosin 2 (beta chain); TPM
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TPM2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit,
细胞定位：
原肌球蛋白抗体产品介绍：background: Tropomyosin is a dimeric coiled coil protein that binds along the length of actin filaments. It is associated with the thin filaments of muscle cells and the microfilaments of nonmuscle cells. Chicken embryo fibroblasts (CEF) contain five isoforms of tropomyosin (a, b, 1, 2, and 3), identified as such by their different apparent molecular masses after separation by SDS-PAGE, but similar biochemical properties, such as resistance to heat and organic solvents, the ability to bind to F actin filaments, and the lack of proline and tryptophan. Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle 原肌球蛋白抗体cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. Subunit: Heterodimer of an alpha and a beta chain. Subcellular Location: Cytoplasm, cytoskeleton. Tissue Specificity: Present in primary breast cancer tissue, absent from normal breast tissue. Post-translational modifications: Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization. DISEASE: Nemaline myopathy 4 (NEM4) [MIM:609285]: A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 4 presents from infancy to childhood with hypotonia and moderate-to-severe proximal weakness with minimal or no progression. Major motor milestones are delayed but independent ambulation is usually achieved, although a wheelchair may be needed in later life. Note=The disease is caused by mutations affecting the gene represented in this entry. Arthrogryposis, distal, 1A (DA1A) [MIM:108120]: 原肌球蛋白抗体A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the tropomyosin family. Gene ID: 7169 Database links: Entrez Gene: 7169 Human Entrez Gene: 22004 Mouse Entrez Gene: 500450 Rat Omim: 190990 Human SwissProt: P07951 Human SwissProt: P58774 Mouse SwissProt: P58775 Rat Unigene: 300772 Human Unigene: 646 Mouse Unigene: 17580 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Trop-2蛋白主要存在于细胞胞质及表面, 它是丝裂原活化蛋白激酶(MAPK)通路的一个重要组成部，参与细胞生长、增殖、分化、死亡及细胞间的功能同步等多种生理过程. Trop-2在很多常见的肿瘤上扮演着重要角色，其中包括乳腺癌、胃癌、结肠癌、肺癌、前列腺癌、胰腺癌和**癌，有学者认为：Trop-2在孕期內所具有的生殖功能可能意味著它同肿瘤的生长有关联。
原肌球蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞凋亡 细胞表面分子 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid