GSK-3结合蛋白FRAT2抗体
规格：1mg/1ml
英文名： FRAT2
别名： Frequently rearranged in advanced T-cell lymphomas 2 antibodyGSK-3 binding protein FRAT2; FRAT2_HUMAN.
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FRAT2
交叉反应：Human, Mouse, Rat, Dog, Cow, Sheep,
细胞定位：
GSK-3结合蛋白FRAT2抗体产品介绍：background: FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin.GSK-3结合蛋白FRAT2抗体 GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins. Function: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. Subunit: Binds GSK-3 GSK-3结合蛋白FRAT2抗体and prevents GSK-3-dependent phosphorylation. Similarity: Belongs to the GSK-3-binding protein family. Database links: UniProtKB/Swiss-Prot: O75474.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GSK-3结合蛋白FRAT2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 干细胞 **细胞 t-**细胞
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid