G1氨基丁酸A型受体α1抗体
规格：1mg/1ml
英文名： GABRA1/GABA A Receptor alpha 1
别名： ECA4; EJM; EJM5; Gaba receptor alpha 1 polypeptide; GABA(A) receptor; GABA(A) receptor subunit alpha 1; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; GABRA 1; GABRA1; Gamma aminobutyric
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GABRA1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
细胞定位：细胞膜 分泌型蛋白
G1氨基丁酸A型受体α1抗体产品介绍：background: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene.G1氨基丁酸A型受体α1抗体 [provided by RefSeq]. Function: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen,G1氨基丁酸A型受体α1抗体 cgp27492 and blocked by phaclofen. Subcellular Location: Secreted and Cell membrane. Tissue Specificity: Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. Similarity: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. Contains 2 Sushi (CCP/SCR) domains. Gene ID: 2554 Database links: Entrez Gene: 2554 Human Entrez Gene: 14394 Mouse Entrez Gene: 29705 Rat Omim: 137160 Human SwissProt: P19150 Chicken SwissProt: P08219 Cow SwissProt: P14867 Human SwissProt: P62812 Mouse SwissProt: P62813 Rat Unigene: 175934 Human Unigene: 439668 Mouse Unigene: 28463 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GABA是**神经系统主要的抑制性神经递质，而GABA-ARα1是GABA的受体之一,在脑内分布*普遍,α1亚单位与其功能密切相关。通过位于脑内的GABA受体发挥抑制性作用GABA及GABA-ARα1在癫痫、颅脑损伤、神经毒剂中毒等**、损伤和中毒模型中的表达、结合都有改变。
G1氨基丁酸A型受体α1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid