甘油吸收/转运蛋白GUP1抗体
规格：1mg/1ml
英文名： HHATL
别名： C3orf3; Glycerol uptake/transporter homolog; GUP1; GUP1 glycerol uptake/transporter homolog; Hedgehog acyltransferase like; Hedgehog acyltransferase-like protein; Hhatl; HHATL_HUMAN; KIAA1173; MBOAT3;
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Human HHATL/GU
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
甘油吸收/转运蛋白GUP1抗体产品介绍：background: GUP1 is a 504 amino acid multipass membrane protein of the endoplasmic reticulum that functions as a membrane bound O-acyltransferase. With specific expression in heart, GUP1 negatively regulates amino-terminal palmitoylation of Shh by HHAT, a protein that is required for Shh signaling. Deletion of the gene encoding GUP1 results in higher sensibility甘油吸收/转运蛋白GUP1抗体 to specific sphinogolipid biosynthesis inhibitors and resistance to ergosterol biosynthesis inhibitors, indicating that GUP1 is an essential component in lipid metabolism. Also, GUP1 also seems to be important for cell wall assembly and stability due to evidence in Saccharomyces cerevisiae GUP1 mutants, which exhibit altered plasma membrane lipid composition and membrane potential. Function: Negatively 甘油吸收/转运蛋白GUP1抗体regulates N-terminal palmitoylation of SHH by HHAT/SKN. Subunit: Interacts with SHH (By similarity). Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Heart-specific. Similarity: Belongs to the membrane-bound acyltransferase family. HHAT subfamily. Database links: Entrez Gene: 57467 Human Entrez Gene: 74770 Mouse Entrez Gene: 301073 Rat Omim: 608116 Human SwissProt: Q9HCP6 Human SwissProt: Q9D1G3 Mouse Unigene: 476041 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
甘油吸收/转运蛋白GUP1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid