转录因子SOX7抗体
规格：1mg/1ml
英文名： SOX7
别名： MGC10895; SOX 7; SOX 7 transcription factor; sox7; SOX7 transcription factor; SOX7_HUMAN; SRY (sex determining region Y) box 7; SRY box 7; SRY sex determining region Y box 7; Transcription factor SOX
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SOX7 (42
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞核
转录因子SOX7抗体产品介绍：background: Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key 转录因子SOX7抗体roles during animal development. Some are involved in human diseases, including sex reversal. Function: Transcriptional repressor. Binds to the DNA sequence 5'-AACAAT-3'. Subunit: Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed in ***** and fetal tissues. Present both in mesenchymal and epithelial cells in some ***** tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation. Similarity: Contains 1 HMG box DNA-binding domain. Contains 1 Sox C-terminal 转录因子SOX7抗体domain. Database links: Entrez Gene: 83595 Human Entrez Gene: 20680 Mouse Entrez Gene: 290317 Rat Entrez Gene: 378665 Xenopus laevis Omim: 612202 Human SwissProt: Q9BT81 Human SwissProt: P40646 Mouse SwissProt: O42342 Xenopus laevis Unigene: 709543 Human Unigene: 42162 Mouse Unigene: 1241 Xenopus laevis Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录因子SOX7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 干细胞 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid