同源盒蛋白NOBOX抗体
规格：1mg/1ml
英文名： NOBOX
别名： Homeobox protein NOBOX; Nobox; NOBOX Oogenesis Homeobox; NOBOX_HUMAN; OG-2; OG2; Og2x; POF5; TCAG_12042.
分子量： 74kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NOBOX (2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
同源盒蛋白NOBOX抗体产品介绍：background: Early ovarian folliculogenesis is characterized by the breakdown of germ cell clusters and formation of primordial follicles. The cessation of ovarian function under the age of 40 years results in premature ovarian failure (POF) and is accompanied by amenorrhea, hypoestrogenism and elevated serum gonadotropin concentrations. 1% of all women are affected by POF, and mutations in a few genes, including inhibin? fsh receptor and the LH/choriogonadotropin receptor have been linked to POF. In addition, several germ cell specific genes and downstream transcription factors are thought to play and important role in human oogenesis. NOBOX同源盒蛋白NOBOX抗体 (newborn ovary homeobox gene), an ooctye-specific homeobox gene, is a critical protein involved in early folliculogenesis. Missense mutations have been shown to cause nonsyndromic ovarian failure by disrupting the NOBOX proteins ability to bind to NOBOX DNA-binding element (NBE), and thereby inhibiting its regulation of Pou5f1 and GDF-9. NOBOX expression in the ovary is oocyte specific, but it shows expression in ***** testis and pancreas as well. Function: Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 同源盒蛋白NOBOX抗体5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Subcellular Location: Nucleus. Tissue Specificity: Expressed in ovaries, testes and pancreas. Expressed within all stages of the ***** female germline, from primordial follicles through to MII oocytes. DISEASE: Defects in NOBOX are the cause of premature ovarian failure type 5 (POF5) [MIM:611548]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. Similarity: Contains 1 homeobox DNA-binding domain. Database links: UniProtKB/Swiss-Prot: O60393.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
同源盒蛋白NOBOX抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 干细胞 转录调节因子 表观遗传学
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid