锌指蛋白195抗体
规格：1mg/1ml
英文名： ZNF195
别名： Zinc finger protein 195; ZNFP104; ZN195_HUMAN .
分子量： 72kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Human ZNF195
交叉反应：Human,
细胞定位：细胞核
锌指蛋白195抗体产品介绍：background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 195 (ZNF195), also known as ZNFP104, is a 629 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF195 is expressed in ***** brain, heart, placenta, pancreas and skeletal muscle and in fetal brain, lung and kidney. ZNF195 contains ten C2H2-type zinc fingers and one KRAB domain through which it is thought to be involved in DNA-binding and transcriptional regulation. Three isoforms of ZNF195 exist as a result of alternative splicing events. Function: Zinc finger proteins are an important class of eukaryotic DNA binding proteins. The zinc finger motif contains spatially conserved cysteines and histidines, which bind a zinc ion. The most common zinc finger motif is the C2H2 type, which wa锌指蛋白195抗体s first identified in the Drosophila segmentation gene, Kruppel. The human genome has several hundred Kruppel related zinc finger genes. About one third of these human Kruppel type genes also code for a highly conserved region, the Kruppel associated box (KRAB domain), comprising approximately 75 amino acids found at the N terminal end. The zinc finger gene ZNF195 contains an N terminal KRAB domain and 14 tandemly repeated Kruppel type zinc finger motifs at its C terminus. ZNF195 may be involved in transcriptional regulation. It is expressed in ***** heart, brain, 锌指蛋白195抗体placenta, skeletal muscle and pancreas, and in foetal lung, kidney and brain. There is little expression in ***** lung, liver and kidney. Subcellular Location: Nuclear Tissue Specificity: Expressed in ***** heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney and brain. There is little expression in ***** lung, liver and kidney. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 10 C2H2-type zinc fingers. Contains 1 KRAB domain. Database links: UniProtKB/Swiss-Prot: O14628.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌指蛋白195抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转录调节因子 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid