钾氯离子转运蛋白KCC4抗体
规格：1mg/1ml
英文名： KCC4
别名： D13Ertd261e; Electroneutral potassium-chloride cotransporter 4; Furosemide sensitive KCl cotransporter 4; K Cl cotransporter KCC4; K-Cl cotransporter 4; Potassium/chloride transporter KCC4; S12A7_HUMA
分子量： 119kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KCC4
交叉反应：Human, Mouse, Rat, Pig, Horse, shk
细胞定位：细胞膜
钾氯离子转运蛋白KCC4抗体产品介绍：background: The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney,钾氯离子转运蛋白KCC4抗体 respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney. Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity:钾氯离子转运蛋白KCC4抗体 Detected in muscle, brain, lung, heart and kidney. Similarity: Belongs to the SLC12A transporter family. Gene ID: 10723 Database links: Entrez Gene: 10723 Human Entrez Gene: 20499 Mouse Entrez Gene: 308069 Rat Omim: 604879 Human SwissProt: Q9Y666 Human SwissProt: Q9WVL3 Mouse SwissProt: Q5RK27 Rat Unigene: 172613 Human Unigene: 275800 Mouse Unigene: 64199 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钾氯离子转运蛋白KCC4抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:10-200 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 通道蛋白 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid