PSD95结合蛋白1抗体
规格：1mg/1ml
英文名： DLGAP1
别名： PSD95 binding protein 1; DAP 1 ALPHA; DAP 1; DAP 1 BETA; DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1; Discs large (Drosophila) homolog associated protein 1; Discs large homolog associated protein 1; Disks la
分子量： 109kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SAPAP1/D
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
PSD95结合蛋白1抗体产品介绍：background: Members of the postsynaptic density-95 (PSD-95)/SAP90 family of membrane-associated guanylate kinase (MAGUK) proteins function as multimodular scaffolds that organize protein-signaling complexes at neuronal synapses. PSD-95/SAP90 binds guanylate kinase-associated protein (GKAP), also designated GK domain-binding protein, DAP-1-a, DAP-1-b, PSD-95 binding protein, PSD-95/SAP90 associated protein, or SAPAP, through the guanylate kinase domain. GKAP is expressed widely in neurons PSD95结合蛋白1抗体of the cortex and hippocampus and in the Purkinje and granule cells of the cerebellum. GKAP is localized specifically in the PSD of glutamatergic synapses, consistent with its direct interaction with PSD-95 family proteins. Function: Part of the postsynaptic scaffold in neuronal cells. Subunit: Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with PSD95结合蛋白1抗体DYL2 and LRFN1 (By similarity). Subcellular Location: Cell membrane. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Found in postsynaptic density of neuronal cells. Tissue Specificity: Expressed in brain. Similarity: Belongs to the SAPAP family. Gene ID: 9229 Database links: Entrez Gene: 9229 Human Entrez Gene: 224997 Mouse Entrez Gene: 65040 Rat Omim: 605445 Human SwissProt: O14490 Human SwissProt: Q9D415 Mouse SwissProt: P97836 Rat Unigene: 654793 Human Unigene: 311840 Mouse Unigene: 367369 Mouse Unigene: 90059 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PSD95结合蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid