烟碱型乙酰胆碱受体α6/AChRα6抗体
规格：1mg/1ml
英文名： CHRNA6
别名： AChR-alpha6; Acra6; Cholinergic receptor nicotinic alpha 6; Cholinergic receptor nicotinic alpha polypeptide 6; CHRNA 6; nAChR alpha 6; NACHRA6; Neuronal acetylcholine receptor subunit alpha 6; Nicoti
分子量： 54kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CHRNA6
交叉反应：Human, Mouse, Rat, Dog, Sheep,
细胞定位：细胞膜
烟碱型乙酰胆碱受体α6/AChRα6抗体产品介绍：background: Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. AChR alpha 6, also designated cholinergic nicotinic receptor alpha polypeptide 6, is a neuronal acetylcholine receptor protein expressed in respiratory mucosa. AChR alpha 6 is also selectively expressed on dopaminergic terminals, where it complexes with AChR Beta 2 and AChR alpha 4. Function: Nicotinic acetylcholine receptors (nAChRs, AChRs) 烟碱型乙酰胆碱受体α6/AChRα6抗体are protein complexes made up of protein subunits that coassemble to form an ion channel. This ion channel is gated through the binding of the neurotransmitter acetylcholine (ACh) to its ligand-binding site on the AChR. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA6 (cholinergic nicotinic receptor alpha polypeptide 6) is a neuronal acetylcholine receptor protein. Subunit: Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Subcellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9)烟碱型乙酰胆碱受体α6/AChRα6抗体 family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-6/CHRNA6 sub-subfamily. Gene ID: 8973 Database links: Entrez Gene: 8973 Human Entrez Gene: 11440 Mouse Entrez Gene: 81721 Rat Omim: 606888 Human SwissProt: Q15825 Human SwissProt: Q9R0W9 Mouse SwissProt: P43143 Rat Unigene: 103128 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
烟碱型乙酰胆碱受体α6/AChRα6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid