脑特异性跨膜蛋白抗体
规格：1mg/1ml
英文名： NETO2
别名： Brain specific transmembrane protein; Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 2; Brain-specific transmembrane protein containing 2 CUB and 1 LD
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NETO2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：细胞膜
脑特异性跨膜蛋白抗体产品介绍：background: This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] Function: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing脑特异性跨膜蛋白抗体 the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission. Subunit: Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors Subcellular Location: Membrane. Post-translational modifications:脑特异性跨膜蛋白抗体 N-glycosylated. Similarity: Contains 2 CUB domains. Contains 1 LDL-receptor class A domain. Gene ID: 81831 Database links: Entrez Gene: 81831 Human Entrez Gene: 74513 Mouse Entrez Gene: 307757 Rat Omim: 607974 Human SwissProt: Q8NC67 Human SwissProt: Q8BNJ6 Mouse SwissProt: C6K2K4 Rat Unigene: 444046 Human Unigene: 126079 Mouse Unigene: 222298 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脑特异性跨膜蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 通道蛋白 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid