无胸腺症相关蛋白DGCR6/迪格奥尔格综合征关键基因6抗体
规格：1mg/1ml
英文名： DGCR6
别名： DGCR 6; DGCR6 protein; DiGeorge syndrome critical region 6; DiGeorge syndrome critical region gene 6; DGCR6_HUMAN.
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DGCR6 (1
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit,
细胞定位：细胞核
无胸腺症相关蛋白DGCR6/迪格奥尔格综合征关键基因6抗体产品介绍：background: Neural crest cell migration to the third and fourth pharyngeal pouches is a critical step in the structural formation of organs that are affected in DiGeorge syndrome. DGCR6 (DiGeorge syndrome critical region 6) is a nuclear protein that plays a role in neural crest cell migration and is located at the DiGeorge syndrome critical region (DGCR) on chromosome 22. Expressed ubiquitously with highest levels in heart, liver and skeletal muscle, DGCR6 shares high homology with the Drosophila gonadal (gdl) protein and with human Laminin ?1, both of which are involved in early tissue development. The gene encoding DGCR6, along with other DGCR genes, is deleted in DiGeorge syndrome; a developmental disorder characterized by improper facial, cardiac and palate formation. Upregulation of DGCR6 is implicated in lung and colon adenocarcinomas, as well as in Burkitt抯 lymphoma and lymphocytes transformed by EBV. Due to a 无胸腺症相关蛋白DGCR6/迪格奥尔格综合征关键基因6抗体duplication of the ancestral DGCR6 locus, there are two functional, highly homologous copies of the DGCR6 gene (designated DGCR6 and DGCR6L) on chromosome 22. Function: DGCR6 shares homology with the Drosophila melanogaster gonadal protein, which participates in gonadal and germ cell development, and with the human laminin gamma-1 chain, which upon polymerization with alpha- and beta-chains forms the laminin molecule. Laminin binds to cells through interaction with a receptor and has functions in cell attachment,无胸腺症相关蛋白DGCR6/迪格奥尔格综合征关键基因6抗体 migration, and tissue organization during development. This protein could be a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome. Subcellular Location: Nucleus. Note=Predominantly nuclear. Tissue Specificity: Found in all tissues examined with highest expression in liver, heart and skeletal muscle. Lower levels in pancreas and placenta. Weak expression in brain. Similarity: Belongs to the gonadal family. Database links: UniProtKB/Swiss-Prot: Q14129.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
无胸腺症相关蛋白DGCR6/迪格奥尔格综合征关键基因6抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 干细胞
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid