帕金森病相关蛋白ATP13A2抗体
规格：1mg/1ml
英文名： ATP13A2
别名： PARK9; AT132_HUMAN; Atp13a2; ATPase type 13A2; CLN12; HSA9947; KRPPD; PARK9; Probable cation transporting ATPase 13A2; Probable cation-transporting ATPase 13A2; Putative ATPase; RP1-37C10.4.
分子量： 129kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ATP13A2
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
帕金森病相关蛋白ATP13A2抗体产品介绍：background: ATP13A2 is a 1,180 amino acid multi-pass membrane protein that belongs to the P5 subfamily of ATPases which play an important role in the transportation of inorganic cations. Expressed as multiple alternative spliced isoforms, ATP13A2 functions to catalyze the conversion of ATP to ADP and a free phosphate, thereby participating in the active transport of ions across cellular membranes. Defects in the gene encoding ATP13A2 are the cause of Kufor-Rakeb syndrome (KRS), a rare hereditary type of Parkinson’s disease that exhibits juvenile onset and is characterized by neurodegeneration and dementia. The ATP13A2 gene maps to human chromosome 1,帕金森病相关蛋白ATP13A2抗体 which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Function: May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Subcellular Location: Membrane; Multi-pass membrane protein (By similarity). Lysosome. Tissue Specificity: Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin-positive dopaminergic neurons (at protein level). DISEASE: Defects in ATP13A2 are the cause of帕金森病相关蛋白ATP13A2抗体 Kufor-Rakeb syndrome (KRS) [MIM:606693]; also known as Parkinson disease type 9 (PARK9). KRS is a rare hereditary disease with juvenile onset. In addition to typical signs of Parkinson disease, affected individuals show symptoms of more widespread neurodegeneration, including dementia. Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. Database links: Entrez Gene: 23400 Human Entrez Gene: 74772 Mouse Entrez Gene: 362645 Rat SwissProt: Q9NQ11 Human SwissProt: Q9CTG6 Mouse Unigene: 128866 Human Unigene: 205625 Mouse Unigene: 19659 Rat Omim: 610513 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
帕金森病相关蛋白ATP13A2抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 信号转导 细胞膜蛋白 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid