胞浆蛋白SH3GL3抗体
规格：1mg/1ml
英文名： SH3GL3
别名： Endophilin I-III; Endophilin-III; CNSA3; EEN 2B L3; EEN B2; EEN2BL3; EENB2; Endophilin 3; Endophilin A3; H.sapiens mRNA for protein containing SH3 domain, SH3GL3; HsT19371; SH3 domain containing GRB2
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SH3GL3 (
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
胞浆蛋白SH3GL3抗体产品介绍：background: The endophilins comprise a family of three SH3 domain-containing proteins designated Endophilin I, II and III, or alternatively known as SH3P4, SH3P8 and SH3P13, respectively. These proteins associate with Amphiphysin, Synaptojanin and Dynamin and are implicated in presynaptic vesicle trafficking at nerve terminals. The expression patterns of the endophilins are consistent with their cellular functions at the neuronal synapse, as Endophilin I is ex- pressed only in the brain. Both Endophilin II and Endophilin III are detected in a variety of tissues. Endophilin I is also implicated in modulating G protein-coupled receptor signaling by functioning as an adapter protein 胞浆蛋白SH3GL3抗体and directing 1 adrenergic receptors to the endocytic machinery. Function: SH3GL3 is implicated in endocytosis and may recruit other proteins to membranes with high curvature. It is found in brain and testis tissue. There are four isoforms. Subunit: Interacts with ARC (By similarity). Interacts with DNM1, SGIP1 and SYNJ1. Interacts with the huntingtin exon 1 protein (HDEX1P) containing a glutamine repeat in the pathological range and promotes formation of insoluble polyglutamine-containing aggregates in vivo. Interacts with DYDC1. Interacts with FASLG. Interacts with ATX2. Subcellular Location: Cytoplasm, early endosome membrane, peripheral membrane protein. Note: Associated with postsynaptic endosomes 胞浆蛋白SH3GL3抗体in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons. Tissue Specificity: Brain and testis. Similarity: Belongs to the endophilin family. Contains 1 BAR domain. Contains 1 SH3 domain. Gene ID: 6457 Database links: Entrez Gene: 6457 Human Entrez Gene: 81921 Rat Omim: 603362 Human SwissProt: Q99963 Human SwissProt: O35180 Rat Unigene: 270055 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胞浆蛋白SH3GL3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid