肌萎缩侧索硬化症相关蛋白FGGY抗体
规格：1mg/1ml
英文名： FGGY
别名： fggy; FGGY carbohydrate kinase domain containing; FGGY carbohydrate kinase domain-containing protein; FGGY_HUMAN; FLJ10986; MGC94804; OTTHUMP00000010078; OTTHUMP00000010081; OTTHUMP00000010082; OTTHUM
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FGGY (15
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：
肌萎缩侧索硬化症相关蛋白FGGY抗体产品介绍：background: FGGY is a 551 amino acid member of the FGGY kinase family that exists as four isoforms which are produced by alternative splicing events. Expressed in lung, kidney, small intestine, liver and fetal brain, FGGY is encoded by a gene that maps to chromosome 1 and, when mutated, is associated with sporadic amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder that affects motor neurons and results in fatal paralysis, usually within 2 to 5 years after initial diagnosis. Chromosome 1, on which the gene encoding FGGY is located, is the largest human chromosome, spanning about 260 million base pairs and making up 8% of the肌萎缩侧索硬化症相关蛋白FGGY抗体 human genome. There are about 3,000 genes on chromosome 1, many of which are associated with genetic diseases, including Hutchinson-Gilford progeria, familial adenomatous polyposis, Stickler syndrome, Gaucher disease and Usher syndrome. Function: Expressed in kidney, lung and small intestine and to a lower extent in liver and detected in cerebrospinal fluid (at protein level). Tissue Specificity:肌萎缩侧索硬化症相关蛋白FGGY抗体 Expressed in fetal brain (at protein level). DISEASE: Defects in FGGY are associated with sporadic amyotrophic lateral sclerosis (ALS) [MIM:105400]. Amyotrophic lateral sclerosis is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. Similarity: Belongs to the FGGY kinase family. Database links: UniProtKB/Swiss-Prot: Q96C11.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肌萎缩侧索硬化症相关蛋白FGGY抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid