蛋白酪氨酸磷酸酶样N前体蛋白抗体
规格：1mg/1ml
英文名： PTPRN
别名： PTPIA2; RPTPN; TPIA2; CA 512; IA 2; IA 2/PTP; IA2; IA2/PTP; ICA 3; ICA 512; ICA3; ICA512; Islet cell antigen 2; Islet cell antigen 512; Islet cell autoantigen 3; Protein tyrosine phosphatase like N; P
分子量： 102kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TPIA2 (5
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞膜
蛋白酪氨酸磷酸酶样N前体蛋白抗体产品介绍：background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] Function: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic蛋白酪氨酸磷酸酶样N前体蛋白抗体 enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Subunit: Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in its cleavage. Subcellular Location: Membrane. Neuroendocrine secretory granules. Tissue Specificity: Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary. Post-translational modifications: Appears to undergo multiple proteolytic cleavage蛋白酪氨酸磷酸酶样N前体蛋白抗体at consecutive basic residues. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Contains 1 tyrosine-protein phosphatase domain. Database links: Entrez Gene: 5798 Human Entrez Gene: 19275 Mouse Entrez Gene: 116660 Rat Entrez Gene: 286810 Cow Omim: 601773 Human SwissProt: P56722 Cow SwissProt: Q16849 Human SwissProt: Q60673 Mouse SwissProt: Q63259 Rat Unigene: 89655 Human Unigene: 2902 Mouse Unigene: 11097 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白酪氨酸磷酸酶样N前体蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid