受体蛋白酪氨酸磷酸酶F抗体
规格：1mg/1ml
英文名： LAR
别名： LAR; LAR protein; LARFN5C; PTPRF; LARS; LCA homolog; Leukocyte antigen related (LAR) PTP receptor; Leukocyte antigen related; Leukocyte antigen related PTP receptor; Leukocyte antigen related tyrosine
分子量： 210kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PTPRF (3
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
受体蛋白酪氨酸磷酸酶F抗体产品介绍：background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of 受体蛋白酪氨酸磷酸酶F抗体obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] Function: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Subunit: Interacts with GRIP1. Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 受体蛋白酪氨酸磷酸酶F抗体Contains 8 fibronectin type-III domains. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 tyrosine-protein phosphatase domains. Database links: Entrez Gene: 5792 Human Entrez Gene: 19268 Mouse Entrez Gene: 360406 Rat Entrez Gene: 12072 Cow Omim: 179590 Human SwissProt: P10586 Human SwissProt: Q5T021 Human SwissProt: Q5T022 Human SwissProt: Q86WS0 Human SwissProt: A2A8L5 Mouse SwissProt: Q9EQ17 Mouse SwissProt: Q64604 Rat Unigene: 272062 Human Unigene: 29855 Mouse Unigene: 11386 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
受体蛋白酪氨酸磷酸酶F抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-400 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid