视神经视网膜相关蛋白VAX1抗体
规格：1mg/1ml
英文名： VAX1
别名： VAX1; VAX1_HUMAN; ventral anterior homeobox 1.
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human VAX1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
细胞定位：细胞核
视神经视网膜相关蛋白VAX1抗体产品介绍：background: The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. VAX1 (ventral anterior homeobox 1) is a 334 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. Expressed as multiple alternatively spliced isoforms, VAX1 is required for major tract formation and axon guidance in the developing brain and may play a role in the differentiation of various structures, including the optic stalk, the neuroretina and the pigmented epithelium. The gene encoding VAX1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Function: 视神经视网膜相关蛋白VAX1抗体Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk. Subcellular Location: Nucleus. DISEASE: Defects in VAX1 are the cause of microphthalmia, syndromic, type 11 (MCOPS11) [MIM:614402]. A rare clinical entity including as main characteristics microphthalmia and small optic nerves, cleft lip and palate, absence of corpus callosum, hippocampal malformations, and absence of the pineal gland. Microphthalmia is a disorder视神经视网膜相关蛋白VAX1抗体 of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. Similarity: Belongs to the EMX homeobox family. Contains 1 homeobox DNA-binding domain. Gene ID: 11023 Database links: Entrez Gene: 11023 Human Entrez Gene: 22326 Mouse Entrez Gene: 64571 Rat Omim: 604294 Human SwissProt: Q5SQQ9 Human SwissProt: Q2NKI2 Mouse SwissProt: Q9JM00 Rat Unigene: 441536 Human Unigene: 23801 Mouse Unigene: 48764 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
视神经视网膜相关蛋白VAX1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid