神经突起生长诱导因子受体Unc5a抗体
规格：1mg/1ml
英文名： Unc5a
别名： UNC5H1; Netrin receptor UNC 5A; Netrin receptor UNC5A; Netrin receptor Unc5h1; Protein unc-5 homolog 1; Protein unc-5 homolog A; Unc 5 homolog 1; Unc 5 homolog A; Unc 5a; Unc5 a; Unc5 homolog 1; Unc5
分子量： 90kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Unc5a
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜
神经突起生长诱导因子受体Unc5a抗体产品介绍：background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events. Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be神经突起生长诱导因子受体Unc5a抗体 caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Subunit: Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC Subcellular Location: Cell membrane. The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones. Post-translational modifications: Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro. Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. Similarity: Belongs to the unc-5 family. Contains 1 death domain.神经突起生长诱导因子受体Unc5a抗体Contains 1 Ig-like (immunoglobulin-like) domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TSP type-1 domain. Contains 1 ZU5 domain. Database links: Entrez Gene: 90249 Human Entrez Gene: 107448 Mouse Entrez Gene: 60629 Rat Omim: 607869 Human SwissProt: Q6ZN44 Human SwissProt: Q8K1S4 Mouse SwissProt: O08721 Rat Unigene: 33191 Human Unigene: 23573 Mouse Unigene: 44433 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经突起生长诱导因子受体Unc5a抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid