轴索过度生长抑制因子B受体抗体
规格：1mg/1ml
英文名： Nogo B receptor
别名： C6orf68; NGBR; nuclear undecaprenyl pyrophosphate synthase 1 homolog; NUS1; NGBR_HUMAN.
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NGBR/Nog
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
轴索过度生长抑制因子B受体抗体产品介绍：background: Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NgBR (Nogo-B receptor), also known as nuclear undecaprenyl pyrophosphate synthase 1 homolog, is a 293 amino acid single-pass type I membrane protein that acts as a specific receptor for the amino-terminus of Nogo-B.轴索过度生长抑制因子B受体抗体 Through this interaction, NgBR is involved in the regulation of vascular remodeling and angiogenesis. NgBR also enhances Niemann-Pick type C2 protein (NPC2) stabilization. Knockdown of NgBR mRNA leads to decreased NPC2 levels, which results in the hallmarks of NPC2 mutation: increased intracellular cholesterol accumulation and a loss of sterol sensing. Function: Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. Able to regulate vascular remodeling and angiogenesis. Its similarity with UPP synthetase proteins轴索过度生长抑制因子B受体抗体 suggests that it may act as a scaffold for the binding of isoprenyl lipids and/or prenylated proteins. Subunit: Interacts with DHDDS, promoting its isoprenyltransferase activity. Interacts with NPC2. Subcellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. Similarity: Belongs to the UPP synthase family. Database links: Entrez Gene: 116150 Human Entrez Gene: 52014 Mouse Entrez Gene: 294400 Rat Omim: 610463 Human SwissProt: Q96E22 Human SwissProt: Q99LJ8 Mouse Unigene: 289008 Human Unigene: 525826 Human Unigene: 199964 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴索过度生长抑制因子B受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid