神经细胞**蛋白Nav1抗体
规格：1mg/1ml
英文名： Neuron navigator 1
别名： Nav 1; Nav1; POMFIL 3; POMFIL3; Pore membrane and/or filament interacting like protein 3; Protein Steerin 1; Protein Steerin1; Steerin 1; Steerin1; unc-53 homolog 1; DKFZp781D0314; FLJ12560; FLJ14203;
分子量： 202kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Neuron n
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig,
细胞定位：细胞浆
神经细胞**蛋白Nav1抗体产品介绍：background: Neuron navigator 1 is a 1877 amino acid cytoplasmic protein that is involved in neuronal migration. Neuron navigtor 1 is widely expressed at low levels, though highest expression is found in both ***** and fetal nervous tissue. Through interaction with tubulin, Neuron navigator 1 associates with a subset of mirotubule plus ends present in the growth cone. Overexpression of Neuron navigator 1 leads to microtubule bundling, whereas a reduction of its levels causes loss of directionality in the migration of pontine cell leading processes. There are seven isoforms of Neuron navigator 1 that are produced as a result of alternative splicing events. Function:神经细胞**蛋白Nav1抗体 The development of the nervous system (NS) requires the coordinated migration of multiple waves of neurons and subsequent processes of neurite maturation, both involving selective guidance mechanisms. In Caenorhabditis elegans, unc-53 codes for a new multidomain protein involved in the directional migration of a subset of cells. We describe here the first functional characterization of the mouse homologue, mouse Neuron navigator 1 (mNAV1) expression is primarily restricted to the CNS during development. mNAV1 is a microtubules associated protein. 神经细胞**蛋白Nav1抗体The abolition of mNAV1 causes loss of directionality in the leading processes of pontine-migrating cells, providing evidence for a role of mNAV1 in mediating (Netrin1-induced) directional migration. Subunit: Interacts with tubulin Subcellular Location: Cytoplasm, cytoskeleton. Note=Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones. Tissue Specificity: Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta. Similarity: Belongs to the Nav/unc-53 family. Database links: UniProtKB/Swiss-Prot: Q8NEY1.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经细胞**蛋白Nav1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit