轴突蛋白1β/Neurexin 1β抗体
规格：1mg/1ml
英文名： Neurexin 1 beta
别名： Neurexin I beta; Neurexin 1; Neurexin 1 beta; Neurexin I beta; NRXN1; NRX1B_HUMAN.
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Neurexin
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
轴突蛋白1β/Neurexin 1β抗体产品介绍：background: Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like轴突蛋白1β/Neurexin 1β抗体 sequences and contain fewer laminin G domains than alpha-neurexins. Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis Subunit: The cytoplasmic C-terminal region轴突蛋白1β/Neurexin 1β抗体 binds to CASK. Isoforms Beta 4b bind neuroligins NLGN1, NLGN2 and NLGN3, alpha-dystroglycan and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2 Subcellular Location: Membrane; Single pass type I membrane protein Post-translational modifications: Highly O-glycosylated and minor N-glycosylated Similarity: Belongs to the neurexin family. Contains 1 laminin G-like domain. Database links: UniProtKB/Swiss-Prot: P58400.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴突蛋白1β/Neurexin 1β抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞粘附分子 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid