丝氨酸或半胱氨酸蛋白水解酶抑制蛋白1抗体
规格：1mg/1ml
英文名： Neuroserpin
别名： Neuroserpin; NEUS_HUMAN; Peptidase inhibitor 12; PI-12; PI12; Protease inhibitor 12; Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1; Serine or cysteine proteinase inhibitor cla
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Neuroser
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：分泌型蛋白
丝氨酸或半胱氨酸蛋白水解酶抑制蛋白1抗体产品介绍：background: Neuroserpin is an axonally secreted glycoprotein in the central nervous system (CNS) that belongs to the family of protease inhibitors known as serpins (1,2). Neuroserpin is a serine-protease inhibitor (3) that forms SDS-stable complexes with tissue plasminogen activator (tPA), urokinase and plasmin, but not thrombin (2,4,5). Neuroserpin is expressed in the neocortex, the hippocampal formation, the olfactory bulb and the amygdala in the ***** CNS, and it is expressed in the cerebellum, the granule cells and a subgroup of Purkinje cells in the developing embryo (2). tPA expression has been linked to "neuronal plasticity"丝氨酸或半胱氨酸蛋白水解酶抑制蛋白1抗体, either in the developing embryo CNS (2,4) or in cases of synpatic remodeling or long-term potentiation (6). Overexpression of tPA may promote neuronal cell death (6). Mutations in the gene which codes for neuroserpin are linked to hereditary dementia (7). Intracerebral administration of neuroserpin after stroke decreases stroke volume and diminishes the apoptotic features of the resulting ischemic penumbra (6). Function: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the ***** nervous system. May protect neurons from cell damage 丝氨酸或半胱氨酸蛋白水解酶抑制蛋白1抗体by tissue-type plasminogen activator. Subcellular Location: Secreted. Tissue Specificity: Predominantly expressed in the brain. DISEASE: Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B) [MIM:604218]. FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Similarity: Belongs to the serpin family. Database links: UniProtKB/Swiss-Prot: Q99574.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝氨酸或半胱氨酸蛋白水解酶抑制蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid