Smad核相互作用蛋白1抗体
规格：1mg/1ml
英文名： SNIP1
别名： FHA domain-containing protein SNIP1; FLJ12553; Smad nuclear interacting protein (Smad nuclear interacting); Smad nuclear interacting protein; Smad nuclear-interacting protein 1; SNIP1 (Smad nuclear in
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SNIP1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞核
Smad核相互作用蛋白1抗体产品介绍：background: Members of the transforming growth factor-beta (TGF-Beta) superfamily play critical roles in controlling cell growth and differentiation. Effects of TGF-Beta family ligands are mediated by Smad proteins. The Smad nuclear interacting protein (SNIP1) contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. SNIP1 potently inhibits the activity of NF-kappa B, which binds the C/H1 domain of CBP/p300, by competing for the binding site. SNIP1 is also thought to induce expression of Cyclin D1 to promote cellular proliferation. SNIP1 is ubiquitously expressed with high expression in heart and skeletal muscle. Smad核相互作用蛋白1抗体Function: Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. Subunit: Binds SMAD4 and CREBBP/EP300. Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Subcellular Location: Nucleus. Tissue Specificity: Tissue specificityUbiquitous, with highest expression in heart and skeletal muscle. Post-translational modifications: Degraded by the proteasome Smad核相互作用蛋白1抗体upon binding to the SMAD1/OAZ1/PSMB4 complex. DISEASE: Defects in SNIP1 are the cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED) [MIM:614501]. A disease characterized by severe psychomotor retardation, intractable seizures, dysmorphic features, and a lumpy skull surface. Patients are hypotonic and have poor feeding in the neonatal period. Similarity: Contains 1 FHA domain. Database links: UniProtKB/Swiss-Prot: Q8TAD8.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Smad核相互作用蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导 生长因子和** 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid