卵黄状黄斑病蛋白2抗体
规格：1mg/1ml
英文名： Bestrophin 2
别名： BEST 2; Best disease Bestrophin; BEST2; Bestrophin2; FLJ20132; Vitelliform macular dystrophy 2 homolog; Vitelliform macular dystrophy 2 like 1; Vitelliform macular dystrophy 2 like protein 1; Vitellif
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Bestroph
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
细胞定位：细胞膜
卵黄状黄斑病蛋白2抗体产品介绍：background: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue卵黄状黄斑病蛋白2抗体 restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin卵黄状黄斑病蛋白2抗体 takes place near the carboxy terminal end of the protein. Function: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Mainly confined to the retinal pigment epithelium and colon. Similarity: Belongs to the bestrophin family. Database links: UniProtKB/Swiss-Prot: Q8NFU1.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
卵黄状黄斑病蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 信号转导 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid