DTX1抗体
规格：1mg/1ml
英文名： Deltex 1
别名： Deltex protein 1; Deltex; Deltex-1; Deltex1; Dtx1; FXI-T1; Fxit 1; Fxit1; mDTX1; DTX1_HUMAN.
分子量： 67kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Deltex-1
交叉反应：Human, Mouse, Rat, Cow,
DTX1抗体细胞定位：细胞核 细胞浆
产品介绍：background: Deltex is a RING finger ubiquitin ligase which is conserved from Drosophila to Humans and is a regulator of Notch signaling pathway. Deltex regulates both B-cell lineage and splenic marginal-zone B-cell commitment. Deltex is implicated in neurogenesis, lymphogenesis and myogenesis as well as marginal zone B cell differentiation. Function: Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, DTX1抗体suggesting that it can antagonize NOTCH1. Subunit: Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 via its N-terminus region and EIF3F, the interaction is required for NOTCH1 deubiquitination. Interacts with EP300. Forms a heterodimer with BBAP; the heterodimerization leading to an increase of in vitro ubiquitin ligase activity. Interacts with ITCH. Subcellular Location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear. Tissue Specificity: Widely expressed. Strongly expressed in blood DTX1抗体vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells. Post-translational modifications: Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. Similarity: Belongs to the Deltex family. Contains 1 RING-type zinc finger. Contains 2 WWE domains. Gene ID: 1840 Database links: Entrez Gene: 1840 Human Entrez Gene: 14357 Mouse Omim: 602582 Human SwissProt: Q86Y01 Human SwissProt: Q61010 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Deltex1用于老年滞呆、神经退行性变的研究。
DTX1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 发育生物学 神经生物学 干细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid