半胱胺酸蛋白酶蛋白-4抗体
规格：1mg/1ml
英文名： Caspase 4
别名： Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP 4; CASP 4; CASP-4; CASP4; CASP4_HUMAN; CASP4_MOUSE; Caspase 4 apoptosis related cysteine peptidase; Caspase-4 subunit 2;
分子量： 20/33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse Caspase
交叉反应：Human, Mouse, Rat, Chicken, Rabbit, ,Daniorerio
半胱胺酸蛋白酶蛋白-4抗体细胞定位：
产品介绍：background: Caspase 4 is a 377 amino acid protein (43 kDa) that belongs to the Ced3/ICE family of cystein proteases. Caspase 4 is an "upstream" caspase with a long prodomain. It undergoes a cleavage upon activation, leading to p20 and p10 subunits which have 67% homology to mature Caspase 1 over the equivalent coding sequences. Caspase 4 is capable of cleaving itself and the p30 Caspase 1 precursor, and of inducing apoptosis in transfected insect or COS cells. In high concentrations, it can also cleave the nuclear DNA enzyme PARP but the半胱胺酸蛋白酶蛋白-4抗体 biological relevance of this cleavage is unclear. Caspase 4 mRNA is found in most tissues examined with the exception of the brain. Highest expression is found in spleen and lung, with moderate expression in heart and liver. Low expression is observed with skeletal muscle, kidney, and testis. Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. Tissue Specificity: Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain. Post-translational modifications: The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8半胱胺酸蛋白酶蛋白-4抗体. Similarity: Belongs to the peptidase C14A family. Contains 1 CARD domain. Gene ID: 12363 Database links: Entrez Gene: 837 Human Entrez Gene: 12363 Mouse Omim: 602664 Human SwissProt: P49662 Human SwissProt: P70343 Mouse Unigene: 138378 Human Unigene: 1569 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
半胱胺酸蛋白酶蛋白-4抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 干细胞 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid